Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

C–H functionalization has been emerging as a powerful method to establish carbon–carbon
and carbon–heteroatom bonds. Many efforts have been devoted to transition-metal …

The development of synthetic methods for the introduction of the fluorine atom and
fluoroalklyl groups into organic molecules has gained increased attention. Synthetic organic …

Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

The efficiency, selectivity and sustainability benefits offered by enzymes are enticing
chemists to consider biocatalytic transformations to complement or even supplant more …

Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …