Structures and general transport mechanisms by the major facilitator superfamily (MFS)
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …
transporters. MFS transporters are responsible for transporting a broad spectrum of …
Bioavailability of bioactive peptides derived from food proteins across the intestinal epithelial membrane: A review
Abstract Background Bioactive peptides (BAPs) play a crucial physiological role in human
health. To exert their biological effects after oral administration, BAPs have to be transported …
health. To exert their biological effects after oral administration, BAPs have to be transported …
Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
M Killer, J Wald, J Pieprzyk, TC Marlovits, C Löw - Science advances, 2021 - science.org
The uptake of peptides in mammals plays a crucial role in nutrition and inflammatory
diseases. This process is mediated by promiscuous transporters of the solute carrier family …
diseases. This process is mediated by promiscuous transporters of the solute carrier family …
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …
Emerging potential of niosomes in ocular delivery
Introduction Niosomes have recently grabbed attention as one of the best tools for various
site-specific drug delivery systems, including ophthalmic drug delivery. Surfactants …
site-specific drug delivery systems, including ophthalmic drug delivery. Surfactants …
[HTML][HTML] Recent advances in understanding proton coupled peptide transport via the POT family
S Newstead - Current opinion in structural biology, 2017 - Elsevier
Highlights•Recent crystal structures reveal insights into ligand promiscuity within the POT
family.•Selectivity pockets play important roles in peptide recognition and …
family.•Selectivity pockets play important roles in peptide recognition and …
Regulation profile of the intestinal peptide transporter 1 (PepT1)
CY Wang, S Liu, XN **e, ZR Tan - Drug design, development and …, 2017 - Taylor & Francis
The intestinal peptide transporter 1 (PepT1) was first identified in 1994. It plays a crucial role
in the absorption of small peptides including not only> 400 different dipeptides and 8,000 …
in the absorption of small peptides including not only> 400 different dipeptides and 8,000 …
Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1
Members of the solute carrier 15 family (SLC15) transport di-and tripeptides as well as
peptidomimetic drugs across the cell membrane. Structures of bacterial homologues have …
peptidomimetic drugs across the cell membrane. Structures of bacterial homologues have …
The structure and mechanism of drug transporters
AG Roberts - Enzyme Kinetics in Drug Metabolism: Fundamentals …, 2021 - Springer
Drug transporters are integral membrane proteins that play a critical role in drug disposition
by affecting absorption, distribution, and excretion. They translocate drugs, as well as …
by affecting absorption, distribution, and excretion. They translocate drugs, as well as …
Food protein structures, functionality and product development
ID Nwachukwu, RE Aluko - 2021 - books.rsc.org
The unique combinations of biological, nutritional and functional properties in proteins make
them important food ingredients with the capacity to provide a range of diverse and highly …
them important food ingredients with the capacity to provide a range of diverse and highly …