Caenorhabditis elegans as a powerful tool in natural product bioactivity research
In addition to synthetic and semisynthetic compounds, natural products have received much
attention as prolific sources of lead compounds with therapeutic effects on various diseases …
attention as prolific sources of lead compounds with therapeutic effects on various diseases …
[HTML][HTML] Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery
Diseases caused by parasitic helminths (worms) represent a major global health burden in
both humans and animals. As vaccines against helminths have yet to achieve a prominent …
both humans and animals. As vaccines against helminths have yet to achieve a prominent …
A high-throughput phenotypic screen of the 'Pandemic Response Box'identifies a quinoline derivative with significant anthelmintic activity
Parasitic nematodes cause diseases in livestock animals and major economic losses to the
agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus …
agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus …
[HTML][HTML] Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans
Global challenges with treatment failures and/or widespread resistance in parasitic worms
against commercially available anthelmintics lend impetus to the development of new …
against commercially available anthelmintics lend impetus to the development of new …
Model nematodes as a practical innovation to promote high throughput screening of natural products for anthelmintics discovery in South Asia: Current challenges …
With the increasing prevalence of anthelmintic resistance in animals recorded globally, and
the threat of resistance in human helminths, the need for novel anthelmintic drugs is greater …
the threat of resistance in human helminths, the need for novel anthelmintic drugs is greater …
Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans
A Bajpai, MA Jackson, YH Huang, K Yap… - Journal of Natural …, 2023 - ACS Publications
Cyclotides are a unique family of stable and cyclic mini-proteins found in plants that have
nematicidal and anthelmintic activities. They are distributed across the Rubiaceae …
nematicidal and anthelmintic activities. They are distributed across the Rubiaceae …
A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automated Caenorhabditis elegans screening platform
F Haerkens, C Kikken, L Kirkels, M van Amstel… - Heliyon, 2022 - cell.com
Obesity is one of the most common global health problems for all age groups with obese
people at risk of a variety of associated health complications. Consequently, there is a need …
people at risk of a variety of associated health complications. Consequently, there is a need …
A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity
Background Infection with parasitic nematodes (helminths), particularly those of the order
Strongylida (such as Haemonchus contortus), can cause significant and burdensome …
Strongylida (such as Haemonchus contortus), can cause significant and burdensome …
[HTML][HTML] Comparative structure activity and target exploration of 1, 2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans
Infections and diseases caused by parasitic nematodes have a major adverse impact on the
health and productivity of animals and humans worldwide. The control of these parasites …
health and productivity of animals and humans worldwide. The control of these parasites …
[HTML][HTML] Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity
Within the context of our anthelmintic discovery program, we recently identified and
evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal …
evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal …