Precision medicine in human heart modeling: perspectives, challenges, and opportunities

M Peirlinck, FS Costabal, J Yao, JM Guccione… - … and modeling in …, 2021 - Springer
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

Models of cardiac tissue electrophysiology: progress, challenges and open questions

RH Clayton, O Bernus, EM Cherry, H Dierckx… - Progress in biophysics …, 2011 - Elsevier
Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

cStress: towards a gold standard for continuous stress assessment in the mobile environment

K Hovsepian, M Al'Absi, E Ertin, T Kamarck… - Proceedings of the …, 2015 - dl.acm.org
Recent advances in mobile health have produced several new models for inferring stress
from wearable sensors. But, the lack of a gold standard is a major hurdle in making clinical …

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

R Piersanti, PC Africa, M Fedele, C Vergara… - Computer Methods in …, 2021 - Elsevier
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …

Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation

F Fenton, A Karma - Chaos: An Interdisciplinary Journal of Nonlinear …, 1998 - pubs.aip.org
Wave propagation in ventricular muscle is rendered highly anisotropic by the intramural
rotation of the fiber. This rotational anisotropy is especially important because it can produce …

Passive material properties of intact ventricular myocardium determined from a cylindrical model

JM Guccione, AD McCulloch, LK Waldman - 1991 - asmedigitalcollection.asme.org
The equatorial region of the canine left ventricle was modeled as a thick-walled cylinder
consisting of an incompressible hyperelastic material with homogeneous exponential …

Multiphysics and multiscale modelling, data–model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics

R Chabiniok, VY Wang… - Interface …, 2016 - royalsocietypublishing.org
With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

The sinoatrial node, a heterogeneous pacemaker structure

MR Boyett, H Honjo, I Kodama - Cardiovascular research, 2000 - academic.oup.com
This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in
terms of cell morphology, pacemaker activity, action potential configuration and conduction …

Left ventricular structure and function: basic science for cardiac imaging

PP Sengupta, J Korinek, M Belohlavek, J Narula… - Journal of the American …, 2006 - jacc.org
The myofiber geometry of the left ventricle (LV) changes gradually from a right-handed helix
in the subendocardium to a left-handed helix in the subepicardium. In this review, we …

Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging

DF Scollan, A Holmes, R Winslow… - American Journal of …, 1998 - journals.physiology.org
Diffusion tensor magnetic resonance imaging (MRI) is a possible new means of elucidating
the anatomic structure of the myocardium. It enjoys several advantages over traditional …