Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
Models of cardiac tissue electrophysiology: progress, challenges and open questions
Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …
Physiome Project, which is an international effort to build biophysically based multi-scale …
cStress: towards a gold standard for continuous stress assessment in the mobile environment
Recent advances in mobile health have produced several new models for inferring stress
from wearable sensors. But, the lack of a gold standard is a major hurdle in making clinical …
from wearable sensors. But, the lack of a gold standard is a major hurdle in making clinical …
Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …
accurately modeling their arrangement is essential for simulating heart electrophysiology …
Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation
Wave propagation in ventricular muscle is rendered highly anisotropic by the intramural
rotation of the fiber. This rotational anisotropy is especially important because it can produce …
rotation of the fiber. This rotational anisotropy is especially important because it can produce …
Passive material properties of intact ventricular myocardium determined from a cylindrical model
JM Guccione, AD McCulloch, LK Waldman - 1991 - asmedigitalcollection.asme.org
The equatorial region of the canine left ventricle was modeled as a thick-walled cylinder
consisting of an incompressible hyperelastic material with homogeneous exponential …
consisting of an incompressible hyperelastic material with homogeneous exponential …
Multiphysics and multiscale modelling, data–model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics
With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …
The sinoatrial node, a heterogeneous pacemaker structure
MR Boyett, H Honjo, I Kodama - Cardiovascular research, 2000 - academic.oup.com
This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in
terms of cell morphology, pacemaker activity, action potential configuration and conduction …
terms of cell morphology, pacemaker activity, action potential configuration and conduction …
Left ventricular structure and function: basic science for cardiac imaging
PP Sengupta, J Korinek, M Belohlavek, J Narula… - Journal of the American …, 2006 - jacc.org
The myofiber geometry of the left ventricle (LV) changes gradually from a right-handed helix
in the subendocardium to a left-handed helix in the subepicardium. In this review, we …
in the subendocardium to a left-handed helix in the subepicardium. In this review, we …
Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging
DF Scollan, A Holmes, R Winslow… - American Journal of …, 1998 - journals.physiology.org
Diffusion tensor magnetic resonance imaging (MRI) is a possible new means of elucidating
the anatomic structure of the myocardium. It enjoys several advantages over traditional …
the anatomic structure of the myocardium. It enjoys several advantages over traditional …