Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment
A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …
Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement
J Domínguez, MJ Boeree, E Cambau… - The Lancet Infectious …, 2023 - thelancet.com
Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …
based methods being considered the gold standard for drug susceptibility testing, molecular …
The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot
Multidrug-resistant tuberculosis (MDR-TB) is among the most frequent causes of death due
to antimicrobial resistance. Although only 3% of global TB cases are MDR, geographical …
to antimicrobial resistance. Although only 3% of global TB cases are MDR, geographical …
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the
largest single contributor to human mortality due to antimicrobial resistance. A few major …
largest single contributor to human mortality due to antimicrobial resistance. A few major …
The molecular clock of Mycobacterium tuberculosis
The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis
Multidrug-resistant tuberculosis (MDR-TB) accounts for one third of the annual deaths due to
antimicrobial resistance. Drug resistance-conferring mutations frequently cause fitness costs …
antimicrobial resistance. Drug resistance-conferring mutations frequently cause fitness costs …
Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era
P Beckert, E Sanchez-Padilla, M Merker, V Dreyer… - Genome Medicine, 2020 - Springer
Abstract Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains
not detected by commercial molecular drug susceptibility testing (mDST) assays due to the …
not detected by commercial molecular drug susceptibility testing (mDST) assays due to the …
High-resolution map** of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain
Y Xu, I Cancino-Muñoz, M Torres-Puente… - PLoS …, 2019 - journals.plos.org
Background Whole genome sequencing provides better delineation of transmission clusters
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai …
Abstract Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex
(MTBC) strains are a serious health problem in India, also contributing to one-fourth of the …
(MTBC) strains are a serious health problem in India, also contributing to one-fourth of the …