Highlights•Online resources facilitate in silico drug-likeness study.•Databases gathering
high quality and up to date data are essential for drug-likeness evaluation.•Web servers for …

Most rare diseases still lack approved treatments despite major advances in research
providing the tools to understand their molecular basis, as well as legislation providing …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Discovering the unintended 'off-targets' that predict adverse drug reactions is daunting by
empirical methods alone. Drugs can act on several protein targets, some of which can be …

Here, we compile the Biopharmaceutics Drug Disposition Classification System (BDDCS)
classification for 927 drugs, which include 30 active metabolites. Of the 897 parent drugs …

In recent years, even with remarkable scientific advancements and a significant increase of
global research and development spending, drugs are frequently withdrawn from markets …

In drug discovery, network‐based approaches are expected to spotlight our understanding
of drug action across multiple layers of information. On one hand, network pharmacology …

Efficient access to chemical information contained in scientific literature, patents, technical
reports, or the web is a pressing need shared by researchers and patent attorneys from …

Abstract DrugCentral (http://drugcentral. org) is an open-access online drug compendium.
DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and …

Academia and small business research units are poised to play an increasing role in drug
discovery, with drug repurposing as one of the major areas of activity. Here we summarize …