Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Microglial cells are responsible for immune surveillance within the CNS. They respond to
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …

Understanding of the causes and underlying mechanisms of pain in people with RA is
rapidly changing. With the advent of more effective disease modifying drugs, joint …

Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of …

Rheumatic and joint diseases, as exemplified by osteoarthritis and rheumatoid arthritis, are
among the most widespread painful and disabling pathologies across the globe. Given the …

Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model
recapitulates both association and dissociation between pain and joint inflammation in RA …

Background Rheumatoid arthritis (RA) patients frequently show weak correlations between
the magnitude of pain and inflammation suggesting that mechanisms other than overt …