Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the
gut. Recent advances in metagenomics and metabolomics have revealed that the gut …

Parkinson's disease (PD) is a complex neurodegenerative disease which is often associated
with gastrointestinal (GI) dysfunction. The GI tract is home to a wide range of …

Objective Prior studies on the gut microbiome in Parkinson's disease (PD) have yielded
conflicting results, and few studies have focused on prodromal (premotor) PD or used …

Importance Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal
microbiota transplantation (FMT) has shown promising effects in preclinical PD models …

Associations between the gut microbiota and Parkinson's disease (PD) have been widely
investigated. However, the replicable biomarkers for PD diagnosis across multiple …

Background Chronic fatigue syndrome (CFS) is a disabling illness of unknown aetiology.
Disruption of gut microbiota may play a role in several neurological disorders. In this study …

Increasing evidence suggests that the gut–brain axis plays a crucial role in Parkinson's
disease (PD). The abnormal accumulation of aggregated alpha-synuclein (aSyn) in the …

Caudo-rostral migration of pathological forms of α-synuclein from the gut to the brain is
proposed as an early feature in Parkinson's disease pathogenesis, but the underlying …

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a
specific progression of pathology from the peripheral to the central nervous system, and this …