From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders

MB VanElzakker, MK Dahlgren, FC Davis… - Neurobiology of learning …, 2014 - Elsevier
Abstract Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a
neutral cue to predict a biologically relevant event: after repeated predictive pairings …

The neurocircuitry of fear, stress, and anxiety disorders

LM Shin, I Liberzon - Neuropsychopharmacology, 2010 - nature.com
Anxiety disorders are a significant problem in the community, and recent neuroimaging
research has focused on determining the brain circuits that underlie them. Research on the …

Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies

MA Fullana, BJ Harrison, C Soriano-Mas… - Molecular …, 2016 - nature.com
Classical Pavlovian fear conditioning remains the most widely employed experimental
model of fear and anxiety, and continues to inform contemporary pathophysiological …

Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala

R Nguyen, K Koukoutselos, T Forro, S Ciocchi - Science Advances, 2023 - science.org
Extinction memory retrieval is influenced by spatial contextual information that determines
responding to conditioned stimuli (CS). However, it is poorly understood whether contextual …

Implicit cognition and addiction: a tool for explaining paradoxical behavior

AW Stacy, RW Wiers - Annual review of clinical psychology, 2010 - annualreviews.org
Research on implicit cognition and addiction has expanded greatly during the past decade.
This research area provides new ways to understand why people engage in behaviors that …

PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry

NG Harnett, AM Goodman, DC Knight - Experimental neurology, 2020 - Elsevier
Although approximately 90% of the US population will experience a traumatic event within
their lifetime, only a fraction of those traumatized individuals will develop posttraumatic …

How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD

T Jovanovic, KJ Ressler - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Exposure to traumatic events that produce extreme fear and horror is all too common in both
military and civilian populations, but not all individuals develop posttraumatic stress disorder …

A meta-analysis of instructed fear studies: implications for conscious appraisal of threat

ML Mechias, A Etkin, R Kalisch - Neuroimage, 2010 - Elsevier
In classical Pavlovian fear conditioning, a neutral stimulus (conditioned stimulus, CS) comes
to be evaluated as threatening due to its association with an aversive stimulus …

Development of anxiety: The role of threat appraisal and fear learning

JC Britton, S Lissek, C Grillon… - Depression and …, 2011 - Wiley Online Library
Anxious individuals exhibit threat biases at multiple levels of information processing. From a
developmental perspective, abnormal safety learning in childhood may establish threat …

Learning: From association to cognition

DR Shanks - Annual review of psychology, 2010 - annualreviews.org
Since the very earliest experimental investigations of learning, tension has existed between
association-based and cognitive theories. Associationism accounts for the phenomena of …