[HTML][HTML] Mechanisms of insulin action and insulin resistance
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
Regulation of hepatic glucose metabolism in health and disease
The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …
during fasting and stores glucose postprandially. However, these hepatic processes are …
One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation
ML Dirks, BT Wall, B Van De Valk, TM Holloway… - Diabetes, 2016 - Am Diabetes Assoc
Short (< 10 days) periods of muscle disuse, often necessary for recovery from illness or
injury, lead to various negative health consequences. The current study investigated …
injury, lead to various negative health consequences. The current study investigated …
Regulation of adipocyte lipolysis
G Frühbeck, L Méndez-Giménez… - Nutrition research …, 2014 - cambridge.org
In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …
Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …
Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes
Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …
Lipid metabolism in sarcopenia
Sarcopenia is an age-related disease associated with loss of muscle mass and strength.
This geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and …
This geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and …
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans
S Sachs, S Zarini, DE Kahn… - American Journal …, 2019 - journals.physiology.org
Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal
role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in …
role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in …
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation
SM Lam, Z Wang, JW Song, Y Shi, WY Liu, LY Wan… - Cell Metabolism, 2025 - cell.com
There exists a pressing need for a non-invasive panel that differentiates mild fibrosis from
non-fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). In this …
non-fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). In this …
Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues
Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new
adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene …
adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene …