A resurgence of tuberculosis has occurred in recent years in the United States and abroad.
Deteriorating public health services, increasing numbers of immigrants from countries of …

Purpose: To summarize major recent developments in tuberculosis and current approaches
to its treatment and prevention. Data Identification: Articles published since 1987 that …

In this study we established the usefulness of DNA fingerprinting for the epidemiology of
tuberculosis on the basis of the DNA polymorphism generated by the insertion sequence …

Mycobacterium tuberculosis complex strains contain a unique chromosomal region, which
consists of multiple 36bp direct repeats (DRs), which are interspersed by unique spacers 35 …

Most strains of the Mycobacterium tuberculosis complex carry multiple copies of an IS3-like
element, and these strains are highly polymorphic with regard to the site of integration in the …

PCR is, in principle, a simple and rapid test for use in the detection of Mycobacterium
tuberculosis. However, virtually no data are available on the reliability and reproducibility of …

IS986 of Mycobacterium tuberculosis belongs to the IS3-like family of insertion sequences,
and it has previously been shown to be present in multiple copies in the chromosome of M …

SUMMARY A polymerase chain reaction (PCR) assay for the rapid detection of
Mycobacterium tuberculosis in sputum samples is described. The target DNA is a 123-base …

We investigated the use of DNA amplification by the polymerase chain reaction reaction
(PCR) for detection of Mycobacterium tuberculosis from clinical specimens. Two-thirds of …

To overcome problems associated with application of PCR to clinical samples, we have
combined a short cultivation procedure with a Salmonella-specific PCR-hybridization assay …