Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Neutrophils act as the body's first line of defense against infection and respond to diverse
inflammatory cues, including cancer. Neutrophils display plasticity, with the ability to adapt …

Despite their cytotoxic capacity, neutrophils are often co-opted by cancers to promote
immunosuppression, tumor growth, and metastasis. Consequently, these cells have …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Chemokines are small secreted proteins that orchestrate migration and positioning of
immune cells within the tissues. Chemokines are essential for the function of the immune …

Primary brain tumors, such as glioblastoma (GBM), are remarkably resistant to
immunotherapy, even though pre-clinical models suggest effectiveness. To understand this …

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a
non-uniform phenotype and diverse functional activities. Both tumor-associated …

Recent years have seen a renaissance in the research linking inflammation and cancer with
immune cells playing a central role in smouldering inflammation in the tumor …

While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance
to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because …