The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

Piperlongumine, also known as piplartine, is an amide alkaloid of Piper longum L.(long
piper), a medical plant known from Ayurvedic medicine. Although was discovered well over …

Natural products have long been an important source for discovery of new drugs to treat
human diseases. Piperlongumine (PL) is an amide alkaloid isolated from Piper longum …

The function of non-coding RNAs (ncRNAs) in the pathogenesis and development of cancer
is indisputable. Molecular mechanisms underlying carcinogenesis involve the aberrant …

Enantioselective Ni‐catalyzed C (sp3)− H bond activation remains an elusive challenge.
Herein, we used phosphine oxide‐ligated Ni− Al bimetallic catalyst to realize …

Selective clearance of senescent cells (SCs) has emerged as a potential therapeutic
approach for age-related diseases, as well as chemotherapy-and radiotherapy-induced …

TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC)
patients without human papillomavirus infection. The recurrence rate for these patients is …

Herein, a series of chiral δ-lactam frameworks have been synthesized and catalyzed by
chiral phosphoric acid (CPA) utilizing two kinds of open-chain aza-dienes and azlactones …

Piplartine (piperlongumine) is a plant-derived molecule that has been receiving intense
interest due to its anticancer characteristics that target the oxidative stress. In the present …

Tubulin, an important target in tumor therapy, is one of the hotspots in the field of
antineoplastic drugs in recent years, and it is of great significance to design and screen new …