Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …

Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …

The liver is vulnerable to sepsis, and sepsis‐induced liver injury is closely associated with
poor survival of sepsis patients. Studies have found that the overproduction of reactive …

Vervet monkeys are among the most widely distributed nonhuman primates, show
considerable phenotypic diversity, and have long been an important biomedical model for a …

Inter-individual variation in gene expression has been shown to be heritable and is often
associated with differences in disease susceptibility between individuals. Many studies …

DNA is replicated according to a defined spatiotemporal program that is linked to both gene
regulation and genome stability. The evolutionary forces that have shaped replication timing …

Transcriptional regulation in response to diverse physiological cues involves complicated
biological processes. Recent initiatives that leverage whole genome sequencing and …

Despite anatomical similarities, there are differences in susceptibility to cardiovascular
disease (CVD) between primates; humans are prone to myocardial ischemia, while …

DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …

Steady-state expression quantitative trait loci (eQTLs) explain only a fraction of disease-
associated loci identified through genome-wide association studies (GWASs), while eQTLs …