The area of transition‐metal‐catalyzed direct arylation through cleavage of C H bonds has
undergone rapid development in recent years, and is becoming an increasingly viable …

Once considered the “holy grail” of organometallic chemistry, synthetically useful reactions
employing CH bond activation have increasingly been developed and applied to natural …

N-Heterocyclic carbenes (NHCs) are cyclic carbenes bearing at least one R-amino
substituent. 1 The most common subclasses of NHCs are represented in Chart 1. Early work …

Direct C–H bond arylation of (hetero) arenes is a very convenient approach for the synthesis
of a wide variety of molecular targets, including compounds of pharmaceutical interest and π …

The concerted metalation− deprotonation mechanism predicts relative reactivity and
regioselectivity for a diverse set of arenes spanning the entire spectrum of known palladium …

The abundance of the biaryl structural motif in natural products, in biologically active
molecules and in materials chemistry has positioned aryl–aryl (Ar–Ar) bond formation high …

Complexes of metals with N-heterocyclic carbene ligands (M/NHC) are typically considered
the systems of choice in homogeneous catalysis due to their stable metal–ligand framework …

A striking breakthrough to the frame of traditional cross-couplings/C− H functionalizations
using an organocatalyst remains unprecedented. We uncovered a conceptually different …

Nitrogen heterocycles are present in many compounds of enormous practical importance,
ranging from pharmaceutical agents and biological probes to electroactive materials. Direct …

Complexes bearing protic N-heterocyclic carbenes (protic NHCs, pNHCs), defined as cyclic
carbenes stabilized by two heteroatoms including at least one NH group, have been less …