The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

Dissecting the regulatory mechanisms controlling mammalian transcripts from production to
degradation requires quantitative measurements of mRNA flow across the cell. We …

Hexanucleotide GGGGCC repeat expansion in C9ORF72 is the most prevalent genetic
cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One …

Abstract DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects
of RNA metabolism including translation initiation and the assembly of stress granules …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short
double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains …

DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the
yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to …

Simple Summary The prevalence of drug resistance has become a global concern,
impacting the effectiveness of various cancer treatments. One of the mechanisms of drug …

Ribonucleoprotein (RNP) granules have been linked to translation regulation and disease,
but their assembly and regulatory mechanisms are not well understood. Here, we show that …