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[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …
while some family members function as Ca 2+-activated anion channels, the majority of …
TMEM16 proteins: unknown structure and confusing functions
The TMEM16 family of membrane proteins, also known as anoctamins, plays key roles in a
variety of physiological functions that range from ion transport to phospholipid scrambling …
variety of physiological functions that range from ion transport to phospholipid scrambling …
Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis
In this study, we combined linkage analysis with whole-exome sequencing of two individuals
to identify candidate causal variants in a moderately-sized UK kindred exhibiting autosomal …
to identify candidate causal variants in a moderately-sized UK kindred exhibiting autosomal …
Missense variants in ANO4 cause sporadic encephalopathic or familial epilepsy with evidence for a dominant-negative effect
F Yang, A Begemann, N Reichhart, A Haeckel… - The American Journal of …, 2024 - cell.com
Anoctamins are a family of Ca 2+-activated proteins that may act as ion channels and/or
phospholipid scramblases with limited understanding of function and disease association …
phospholipid scramblases with limited understanding of function and disease association …
Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F
TMEM16F, which is activated by elevation of intracellular calcium to trigger phospholipid
scrambling and the collapse of lipid bilayer asymmetry to mediate important cellular …
scrambling and the collapse of lipid bilayer asymmetry to mediate important cellular …
Gain of function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia
Mutations in the human TMEM16E (ANO5) gene are associated both with the bone disease
gnathodiaphyseal dysplasia (GDD; OMIM: 166260) and muscle dystrophies (OMIM: 611307 …
gnathodiaphyseal dysplasia (GDD; OMIM: 166260) and muscle dystrophies (OMIM: 611307 …
[HTML][HTML] Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis
Fine control over chloride homeostasis in the lung is required to maintain membrane
excitability, transepithelial transport as well as intra-and extracellular ion and water …
excitability, transepithelial transport as well as intra-and extracellular ion and water …
Gating and regulatory mechanisms of TMEM16 ion channels and scramblases
The transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels
and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop …
and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop …
Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels
K Vocke, K Dauner, A Hahn, A Ulbrich… - Journal of General …, 2013 - rupress.org
Ca2+-dependent ClJ currents contribute to a large variety of regulatory processes, including
secretory activities in various epithelia, blood pressure control in vascular smooth muscle …
secretory activities in various epithelia, blood pressure control in vascular smooth muscle …
[HTML][HTML] Polymodal control of TMEM16x channels and scramblases
E Agostinelli, P Tammaro - International Journal of Molecular Sciences, 2022 - mdpi.com
The TMEM16A/anoctamin-1 calcium-activated chloride channel (CaCC) contributes to a
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …