Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

Topoisomerases regulate the topological state of cellular genomes to prevent impediments
to vital cellular processes, including replication and transcription from suboptimal …

Type IA topoisomerases (TopoIAs) are present in all living organisms. They resolve
DNA/RNA catenanes, knots and supercoils by breaking and rejoining single-stranded …

The present study demonstrates how TOP3B is involved in resolving R-loops. We observed
elevated R-loops in TOP3B knockout cells (TOP3BKO), which are suppressed by TOP3B …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

Abstract Topoisomerase IIIα (TOP3A) belongs to the conserved Type IA family of DNA
topoisomerases. Here we report that human TOP3A is associated with DNA replication forks …

TOP3B is stabilized by TDRD3. Hypothesizing that TDRD3 recruits a deubiquitinase, we find
that TOP3B interacts with USP9X via TDRD3. Inactivation of USP9X destabilizes TOP3B …

Abstract Topoisomerases (TOP1, TOP2α, and β) are nuclear enzymes crucial for virtually all
aspects of DNA metabolisms. They also are the targets of important anti-tumor …

R-loops are abundant and dynamic structures ubiquitously present in human cells both in
the nuclear and mitochondrial genomes. They form in cis in the wake of transcription …

DNA-protein cross-links (DPCs) are among the most detrimental genomic lesions. They are
ubiquitously produced by formaldehyde (FA), and failure to repair FA-induced DPCs blocks …