Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

The targeted repair of mutant protooncogenes or the inactivation of their gene products may
be a specific and effective therapy for human neoplasia. To examine this possibility, we have …

Ras proteins are guanine nucleotide–binding proteins that play pivotal roles in the control of
normal and transformed cell growth and are among the most intensively studied proteins of …

Desiccation of plants during drought can be detrimental to agricultural production. The
phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in …

Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …

A series of alterations in the cellular genome affecting the expression or function of genes
controlling cell growth and differentiation is considered to be the main cause of cancer …

In the course of combating infectious agents, type I interferon (IFN) needs a timely
downregulation mechanism to avoid detrimental overreaction. Here we showed a …

Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors–HMG-CoA reductase
inhibitors) have been approved for the treatment of lipid disorders. Recently, in vivo studies …