Biochemistry and genetics of von Willebrand factor
JE Sadler - Annual review of biochemistry, 1998 - annualreviews.org
Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …
Sorting and storage during secretory granule biogenesis: looking backward and looking forward
P ARVAN, D CASTLE - Biochemical Journal, 1998 - portlandpress.com
Secretory granules are specialized intracellular organelles that serve as a storage pool for
selected secretory products. The exocytosis of secretory granules is markedly amplified …
selected secretory products. The exocytosis of secretory granules is markedly amplified …
VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.
S Monier, RG Parton, F Vogel, J Behlke… - Molecular biology of …, 1995 - Am Soc Cell Biol
VIP21-caveolin is a membrane protein, proposed to be a component of the striated coat
covering the cytoplasmic surface of caveolae. To investigate the biochemical composition of …
covering the cytoplasmic surface of caveolae. To investigate the biochemical composition of …
Functional architecture of Weibel-Palade bodies
KM Valentijn, JE Sadler, JA Valentijn… - Blood, The Journal …, 2011 - ashpublications.org
Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …
Dynamics and plasticity of Weibel-Palade bodies in endothelial cells
MG Rondaij, R Bierings, A Kragt… - … , and vascular biology, 2006 - Am Heart Assoc
Agonist-induced release of endothelial cell specific storage granules, designated Weibel-
Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to …
Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to …
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor
Endothelial secretion of von Willebrand factor (VWF) from intracellular organelles known as
Weibel-Palade bodies (WPBs) is required for platelet adhesion to the injured vessel wall …
Weibel-Palade bodies (WPBs) is required for platelet adhesion to the injured vessel wall …
The manifold cellular functions of von willebrand factor
A Mojzisch, MA Brehm - Cells, 2021 - mdpi.com
The plasma glycoprotein von Willebrand factor (VWF) is exclusively synthesized in
endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets. Its primary …
endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets. Its primary …
The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin
DD Wagner - Thrombosis and haemostasis, 1993 - thieme-connect.com
Endothelial cells of most blood vessels contain elongated granules called Weibel-Palade
bodies which are not found in any other cell type (Fig. 1)(1). These membrane-bound …
bodies which are not found in any other cell type (Fig. 1)(1). These membrane-bound …
von Willebrand factor propeptide: biology and clinical utility
SL Haberichter - Blood, The Journal of the American Society of …, 2015 - ashpublications.org
Abstract von Willebrand factor (VWF) is a large multimeric glycoprotein that mediates the
attachment of platelets to damaged endothelium and also serves as the carrier protein for …
attachment of platelets to damaged endothelium and also serves as the carrier protein for …
Formation and function of Weibel-Palade bodies
Weibel-Palade bodies (WPBs) are secretory organelles used for post-synthesis storage in
endothelial cells that can, very rapidly, be triggered to release their contents. They carry a …
endothelial cells that can, very rapidly, be triggered to release their contents. They carry a …