Early detection and monitoring are critical to the diagnosis and management of glaucoma, a
progressive optic neuropathy that causes irreversible blindness. Optical coherence …

The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal
neovascularization, which is a major cause of vision loss worldwide, leads to corneal …

Significance: Measurement and imaging of hemoglobin oxygenation are used extensively in
the detection and diagnosis of disease; however, the applied instruments vary widely in their …

Assessing oxygen saturation (sO2) remains challenging but is nonetheless necessary for
understanding retinal metabolism. We and others previously achieved oximetry on major …

Similar to other organs, the retina relies on tightly regulated perfusion and oxygenation.
Previous studies have demonstrated that retinal blood flow is affected in a variety of eye and …

Visible light optical coherence tomography (OCT) theoretically provides finer axial resolution
than near-infrared OCT for a given wavelength bandwidth. To realize this potential in the …

The intimate relationship between neuronal activity and cerebral oxygenation underpins
fundamental brain functions like cognition, sensation, and motor control. Optical imaging …

We longitudinally imaged both the superficial and deep cortical microvascular networks in
brains of healthy mice and in a mouse model of stroke in vivo using visible-light optical …

Background The capabilities of visible-light optical coherence tomography (vis-OCT) in
noninvasive anatomical and functional retinal imaging have been demonstrated by multiple …

Measurement of blood oxygen saturation (s O2) by optical imaging oximetry provides
invaluable insight into local tissue functions and metabolism. Despite different embodiments …