[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism

V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

A brief history of autophagy from cell biology to physiology and disease

N Mizushima - Nature cell biology, 2018 - nature.com
The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …

Autophagy balances inflammation in innate immunity

V Deretic, B Levine - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One
of the pivotal contributions of autophagy in immunity is the cell autonomous control of …

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

H Chu, A Khosravi, IP Kusumawardhani, AHK Kwon… - Science, 2016 - science.org
Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and
dysbiosis of the gut microbiome, though unifying principles for these findings remain largely …

Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis

K Cadwell - Nature Reviews Immunology, 2016 - nature.com
Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

Autophagy and inflammation

Y Matsuzawa-Ishimoto, S Hwang… - Annual review of …, 2018 - annualreviews.org
The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …

Autophagy restricts Mycobacterium tuberculosis during acute infection in mice

GR Golovkine, AW Roberts, HM Morrison… - Nature …, 2023 - nature.com
Whether or not autophagy has a role in defence against Mycobacterium tuberculosis
infection remains unresolved. Previously, conditional knockdown of the core autophagy …

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

P Mehrbod, SR Ande, J Alizadeh, S Rahimizadeh… - Virulence, 2019 - Taylor & Francis
Virus infection induces different cellular responses in infected cells. These include cellular
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …

Autophagy regulation of metabolism is required for CD8+ T cell anti-tumor immunity

L DeVorkin, N Pavey, G Carleton, A Comber, C Ho… - Cell reports, 2019 - cell.com
Autophagy is a cell survival process essential for the regulation of immune responses to
infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here …

[HTML][HTML] Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production

J Xu, L Kong, BA Oliver, B Li, EA Creasey, G Guzman… - Cell reports, 2023 - cell.com
Autophagy is an essential cellular process that is deeply integrated with innate immune
signaling; however, studies that examine the impact of autophagic modulation in the context …