BACKGROUND: Practice guidelines reflect published literature. Because of the ever
changing literature base, it is necessary to update and revise guideline recommendations …

Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …

Point-of-care (POC) assays are available for a variety of coagulation tests. These assays are
generally simple to perform and have a more rapid turnaround time than their central …

Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient, which when implemented may improve patient outcomes …

Background Antifibrinolytic agents are commonly used during cardiac surgery to minimize
bleeding and to reduce exposure to blood products. We sought to determine whether …

It is essential that the medical profession play a significant role in critically evaluating the use
of diagnostic procedures and therapies as they are introduced and tested in the detection …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

Uncontrolled bleeding remains the leading cause of morbidity and mortality across the entire
macrocosm. It refers to excessive loss of blood that occurs inside of body, due to …