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Establishing neuronal diversity in the spinal cord: a time and a place
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …
arranged in characteristic positions. During development, these different types of neurons …
Motor neurons and the generation of spinal motor neuron diversity
N Stifani - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord
Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …
mechanisms underlying this relationship remain poorly understood. Here, to address this …
[HTML][HTML] Hox genes in development and beyond
KA Hubert, DM Wellik - Development, 2023 - journals.biologists.com
Hox genes encode evolutionarily conserved transcription factors that are essential for the
proper development of bilaterian organisms. Hox genes are unique because they are …
proper development of bilaterian organisms. Hox genes are unique because they are …
Hox genes: choreographers in neural development, architects of circuit organization
P Philippidou, JS Dasen - Neuron, 2013 - cell.com
The neural circuits governing vital behaviors, such as respiration and locomotion, are
comprised of discrete neuronal populations residing within the brainstem and spinal cord …
comprised of discrete neuronal populations residing within the brainstem and spinal cord …
Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells
T Ogura, H Sakaguchi, S Miyamoto… - …, 2018 - journals.biologists.com
The spinal cord contains more than 20 distinct subclasses of neurons that form well-
organized neural circuits capable of sensing the environment and generating motor …
organized neural circuits capable of sensing the environment and generating motor …
[HTML][HTML] Human HOX gene disorders
SC Quinonez, JW Innis - Molecular genetics and metabolism, 2014 - Elsevier
The Hox genes are an evolutionarily conserved family of genes, which encode a class of
important transcription factors that function in numerous developmental processes …
important transcription factors that function in numerous developmental processes …
How to make spinal motor neurons
BN Davis-Dusenbery, LA Williams, JR Klim… - …, 2014 - journals.biologists.com
All muscle movements, including breathing, walking, and fine motor skills rely on the
function of the spinal motor neuron to transmit signals from the brain to individual muscle …
function of the spinal motor neuron to transmit signals from the brain to individual muscle …
Development of the diaphragm–a skeletal muscle essential for mammalian respiration
AJ Merrell, G Kardon - The FEBS journal, 2013 - Wiley Online Library
The mammalian diaphragm muscle is essential for respiration, and thus is one of the most
critical skeletal muscles in the human body. Defects in diaphragm development leading to …
critical skeletal muscles in the human body. Defects in diaphragm development leading to …
The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation
AJ Linares, CH Lin, A Damianov, KL Adams… - Elife, 2015 - elifesciences.org
The RNA-binding proteins PTBP1 and PTBP2 control programs of alternative splicing during
neuronal development. PTBP2 was found to maintain embryonic splicing patterns of many …
neuronal development. PTBP2 was found to maintain embryonic splicing patterns of many …