Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …

Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …

A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …

Over the past decade, advances in both molecular developmental biology and evolutionary
ecology have made possible a new understanding of organisms as dynamic systems …

For more than a century, clinical investigators have focused on early life as a source of adult
psychopathology. Early theories about psychic conflict and toxic parenting have been …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Epigenetic modifications of DNA and histones might be crucial for understanding the
molecular basis of complex phenotypes. One reason for this is that epigenetic factors are …