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Bile acids and their receptors in metabolic disorders
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
Adapting to obesity with adipose tissue inflammation
Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …
senses nutrient status and regulates energy mobilization. An overall positive energy balance …
[HTML][HTML] Adipose tissue and metabolic health
In this review, we provide a brief synopsis of the connections between adipose tissue and
metabolic health and highlight some recent developments in understanding and exploiting …
metabolic health and highlight some recent developments in understanding and exploiting …
Brown and beige fat: physiological roles beyond heat generation
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …
Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …
Understanding the physiology of FGF21
FM Fisher, E Maratos-Flier - Annual review of physiology, 2016 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
Treatment of nonalcoholic fatty liver disease: role of AMPK
Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …
Restoration of metabolic health by decreased consumption of branched‐chain amino acids
Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for
maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism …
maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism …
FGF21 gene therapy as treatment for obesity and insulin resistance
V Jimenez, C Jambrina, E Casana… - EMBO molecular …, 2018 - embopress.org
Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently
available therapies are not suited for all patients in the heterogeneous obese/T2D …
available therapies are not suited for all patients in the heterogeneous obese/T2D …