Background Angiogenesis is a key and early step in tumorigenesis, and is known as a
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …

The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

The tumor microenvironment is a complex system, playing an important role in tumor
development and progression. Besides cellular stromal components, extracellular matrix …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Vascular normalization is a new concept of targeting angiogenesis to restore vessel
structure and function and to increase blood perfusion and delivery of drugs. It has been …

Bone formation and regeneration is a multistep complex process crucially determined by the
formation of blood vessels in the growth plate region. This is preceded by the expression of …

Hypoxia, a common factor ruling the microenvironment composition, leads to tumor
progression. In this hypoxic context, cytokines and cells cooperate to favor cancer …

SNAIL (SNAI1) is a zinc finger transcription factor that binds to E-box sequences and
regulates the expression of genes. It usually acts as a gene repressor, but it may also …

Tumour microenvironment determines the fate of treatments. Reconstitution of tumour
conditions is mandatory for alternative in vitro methods devoted to cancer development and …