Human epithelial organoids—3D spheroids derived from adult tissue stem cells—enable
investigation of epithelial physiology and disease and host interactions with …

Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …

Laboratory studies of host–microbe interactions have historically been carried out using
transformed cell lines and animal models. Although much has been learned from these …

Gastrointestinal infections cause significant morbidity and mortality worldwide. The
complexity of human biology and limited insights into host-specific infection mechanisms are …

Foodborne bacterial infections caused by pathogens are a widespread problem in the
Middle East, leading to significant economic losses and negative impacts on public health …

The human gastrointestinal mucosal surface consists of a eukaryotic epithelium, a
prokaryotic microbiota, and a carbohydrate-rich interface that separates them. In the …

The intestinal mucus layer has a dual role in human health constituting a well-known
microbial niche that supports gut microbiota maintenance but also acting as a physical …

Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for
understanding the physiology of the human intestinal epithelium. Here, we explored the …

There are different models available that mimic the human intestinal epithelium and are thus
available for studying probiotic and pathogen interactions in the gastrointestinal tract …

Enterobacterial pathogens infect the gut by a multistep process, resulting in colonization of
both the lumen and the mucosal epithelium. Due to experimental constraints, it remains …