The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor
immunity, but the mechanisms governing their cellular redox homeostasis remain elusive …

Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

T cells are an important component of adaptive immunity and protect the host from infectious
diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Recent studies indicate that cellular metabolism plays a key role in supporting immune cell
maintenance and development. Here, we review how metabolism guides immune cell …

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …