Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …

Develo** therapeutic molecules that target chondrocytes and locally produced
inflammatory factors within arthritic cartilage is an active area of investigation. The extensive …

A major challenge in tissue engineering is the development of materials that can support
angiogenesis, wherein endothelial cells from existing vasculature invade the surrounding …

Background: Delivery of anticancer therapeutic agents to solid tumors is problematic.
Macromolecular drug carriers are an attractive alternative drug delivery method because …

Translational motion in solution, either diffusion or fluid flow, is at the heart of chemical and
biochemical reactivity. Nuclear Magnetic Resonance (NMR) provides a powerful non …

von Willebrand factor (VWF), a protein present in our circulatory system, is necessary to stop
bleeding under high shear-stress conditions as found in small blood vessels. The results …

The reader of this chapter may draw inspiration from the following quote from research
biologist Albert Harris (Harris, 1994):“Systems of interacting forces and stimuli don't have to …

Background Computational modeling of cardiovascular flow is a growing and useful field,
but such simulations usually require the researcher to guess the flow's inlet and outlet …

Fig. 20.1 Macular Bruch's membrane throughout the lifespan. Retinal pigment epithelium
(RPE) is at the top of all panels. RPE basal lamina (arrowheads) and elastic layer (EL …

During metastasis, cancer cells enter the circulation in order to gain access to distant
tissues, but how this fluid microenvironment influences cancer cell biology is poorly …