The infant gut virome is associated with preschool asthma risk independently of bacteria

C Leal Rodríguez, SA Shah, MA Rasmussen… - Nature Medicine, 2024‏ - nature.com
Bacteriophage (also known as phage) communities that inhabit the gut have a major effect
on the structure and functioning of bacterial populations, but their roles and association with …

The never-ending battle between lactic acid bacteria and their phages

C Philippe, JK Cornuault, AG de Melo… - FEMS Microbiology …, 2023‏ - academic.oup.com
Over the past few decades, the interest in lactic acid bacteria (LAB) has been steadily
growing. This is mainly due to their industrial use, their health benefits as probiotic bacteria …

PhageScope: a well-annotated bacteriophage database with automatic analyses and visualizations

RH Wang, S Yang, Z Liu, Y Zhang, X Wang… - Nucleic acids …, 2024‏ - academic.oup.com
Bacteriophages are viruses that infect bacteria or archaea. Understanding the diverse and
intricate genomic architectures of phages is essential to study microbial ecosystems and …

[HTML][HTML] Bacteriophage communities are a reservoir of unexplored microbial diversity in neonatal health and disease

GR Young, A Nelson, CJ Stewart, DL Smith - Current Opinion in …, 2023‏ - Elsevier
Acquisition and development of the gut microbiome are vital for immune education in
neonates, especially those born preterm. As such, microbial communities have been …

[HTML][HTML] Infant gut DNA bacteriophage strain persistence during the first 3 years of life

YC Lou, LX Chen, AL Borges, J West-Roberts… - Cell Host & Microbe, 2024‏ - cell.com
Bacteriophages are key components of gut microbiomes, yet the phage colonization process
in the infant gut remains uncertain. Here, we establish a large phage sequence database …

An extended catalog of integrated prophages in the infant and adult fecal microbiome shows high prevalence of lysogeny

E Dikareva, D Matharu, E Lahtinen, KL Kolho… - Frontiers in …, 2023‏ - frontiersin.org
Background and aims The acquisition and gradual maturation of gut microbial communities
during early childhood is central to an individual's healthy development. Bacteriophages …

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

TS Rasmussen, X Mao, S Forster, SB Larsen… - Microbiome, 2024‏ - Springer
Background Fecal microbiota transplantation (FMT) and fecal virome transplantation (FVT,
sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile …

Escherichia coli CRISPR arrays from early life fecal samples preferentially target prophages

MB Dion, SA Shah, L Deng, J Thorsen… - The ISME …, 2024‏ - academic.oup.com
CRISPR–Cas systems are defense mechanisms against phages and other nucleic acids
that invade bacteria and archaea. In Escherichia coli, it is generally accepted that CRISPR …

Viromes vs. mixed community metagenomes: choice of method dictates interpretation of viral community ecology

JC Kosmopoulos, KM Klier, MV Langwig, PQ Tran… - Microbiome, 2024‏ - Springer
Background Viruses, the majority of which are uncultivated, are among the most abundant
biological entities on Earth. From altering microbial physiology to driving community …

A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics

Y Peng, J Zhu, S Wang, Y Liu, X Liu, O DeLeon… - Cell Host & Microbe, 2024‏ - cell.com
Existing microbiota databases are biased toward adult samples, hampering accurate
profiling of the infant gut microbiome. Here, we generated a metagenome-assembled …