Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …

The large Amino Acid Transporter 1 (LAT1) is an interesting target in drug discovery since
this transporter is overexpressed in several human cancers. Furthermore, due to its location …

Structural and functional characterization of proteins as well as the design of targeted drugs
heavily rely on recombinant protein expression and purification. The polyhistidine-tag (His …

Cryo-EM structure determination of relatively small and flexible membrane proteins at high
resolution is challenging. Increasing the size and structural features by binding of high …

Transmembrane carriers of the Slc11 family catalyze proton (H+)-dependent uptake of
divalent metal ions (Me2+) such as manganese and iron—vital elements coveted during …

Accurately characterizing molecular interactions stands as a pivotal requirement for
ensuring the reliability of molecular dynamics simulations. In line with our bond-dipole …

Arginine‐ornithine metabolism plays a crucial role in bacterial homeostasis, as evidenced
by numerous studies. However, the utilization of arginine and the downstream products of its …

FurE is a H+ symporter specific for the cellular uptake of uric acid, allantoin, uracil, and toxic
nucleobase analogues in the fungus Aspergillus nidulans. Being member of the NCS1 …

An aspartate: alanine antiporter (AspT) from the lactic acid bacterium Tetragenococcus
halophilus catalyzes the electrogenic aspartate1-: alanine0 exchange reaction. Our previous …

Most membrane protein molecules undergo conformational changes as they transition from
one functional state to another one. An understanding of the mechanism underlying these …