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Understanding apoptosis and apoptotic pathways targeted cancer therapeutics
R Jan - Advanced pharmaceutical bulletin, 2019 - pmc.ncbi.nlm.nih.gov
Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …
Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics
Cancer is a multifactorial, multi-stage disease, including complex cascades of signaling
pathways—the cell growth governed by dysregulated and abrupt cell division. Due to the …
pathways—the cell growth governed by dysregulated and abrupt cell division. Due to the …
[HTML][HTML] H2AX: A key player in DNA damage response and a promising target for cancer therapy
Cancer is caused by a complex interaction of factors that interrupt the normal growth and
division of cells. At the center of this process is the intricate relationship between DNA …
division of cells. At the center of this process is the intricate relationship between DNA …
Cadmium exposure: mechanisms and pathways of toxicity and implications for human health
F Qu, W Zheng - Toxics, 2024 - mdpi.com
Cadmium (Cd), a prevalent environmental contaminant, exerts widespread toxic effects on
human health through various biochemical and molecular mechanisms. This review …
human health through various biochemical and molecular mechanisms. This review …
Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses
Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …
[HTML][HTML] The endoplasmic reticulum–mitochondria connection: one touch, multiple functions
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a
characteristic “network structure” that facilitates the formation of interorganellar connections …
characteristic “network structure” that facilitates the formation of interorganellar connections …
Mitochondria‐ros crosstalk in the control of cell death and aging
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players
The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
There is a growing consensus that the various forms of cell death (necrosis, apoptosis and
autophagy) are not separated by strict boundaries, but rather share molecular effectors and …
autophagy) are not separated by strict boundaries, but rather share molecular effectors and …
Mitochondrial Ca2+ and apoptosis
Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …
large body of experimental evidence has unambiguously revealed that, in addition to the …