Understanding apoptosis and apoptotic pathways targeted cancer therapeutics

R Jan - Advanced pharmaceutical bulletin, 2019 - pmc.ncbi.nlm.nih.gov
Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics

GS Chaudhry, A Md Akim, YY Sung… - Frontiers in …, 2022 - frontiersin.org
Cancer is a multifactorial, multi-stage disease, including complex cascades of signaling
pathways—the cell growth governed by dysregulated and abrupt cell division. Due to the …

[HTML][HTML] H2AX: A key player in DNA damage response and a promising target for cancer therapy

KS Prabhu, S Kuttikrishnan, N Ahmad… - Biomedicine & …, 2024 - Elsevier
Cancer is caused by a complex interaction of factors that interrupt the normal growth and
division of cells. At the center of this process is the intricate relationship between DNA …

Cadmium exposure: mechanisms and pathways of toxicity and implications for human health

F Qu, W Zheng - Toxics, 2024 - mdpi.com
Cadmium (Cd), a prevalent environmental contaminant, exerts widespread toxic effects on
human health through various biochemical and molecular mechanisms. This review …

Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses

A Carreras-Sureda, P Pihán, C Hetz - Cell calcium, 2018 - Elsevier
Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …

[HTML][HTML] The endoplasmic reticulum–mitochondria connection: one touch, multiple functions

S Marchi, S Patergnani, P Pinton - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a
characteristic “network structure” that facilitates the formation of interorganellar connections …

Mitochondria‐ros crosstalk in the control of cell death and aging

S Marchi, C Giorgi, JM Suski… - Journal of signal …, 2012 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …

ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players

E Bahar, H Kim, H Yoon - International journal of molecular sciences, 2016 - mdpi.com
The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

P Pinton, C Giorgi, R Siviero, E Zecchini, R Rizzuto - Oncogene, 2008 - nature.com
There is a growing consensus that the various forms of cell death (necrosis, apoptosis and
autophagy) are not separated by strict boundaries, but rather share molecular effectors and …

Mitochondrial Ca2+ and apoptosis

C Giorgi, F Baldassari, A Bononi, M Bonora… - Cell calcium, 2012 - Elsevier
Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …