Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives
Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …
function, but also in pathophysiology, and are associated with protection from numerous …
The intersection of flow cytometry with microfluidics and microfabrication
A modern flow cytometer can analyze and sort particles on a one by one basis at rates of 50
000 particles per second. Flow cytometers can also measure as many as 17 channels of …
000 particles per second. Flow cytometers can also measure as many as 17 channels of …
Receptor–ligand binding assays: technologies and applications
LAA De Jong, DRA Uges, JP Franke… - Journal of chromatography …, 2005 - Elsevier
Receptor–ligand interactions play a crucial role in biological systems and their
measurement forms an important part of modern pharmaceutical development. Numerous …
measurement forms an important part of modern pharmaceutical development. Numerous …
Inertial manipulation and transfer of microparticles across laminar fluid streams
A general strategy for controlling particle movement across streams would enable new
capabilities in single‐cell analysis, solid‐phase reaction control, and biophysics research …
capabilities in single‐cell analysis, solid‐phase reaction control, and biophysics research …
Rolling on E-or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
Human blood neutrophils rolling on E-or P-selectin reduced their rolling velocity when
intercellular adhesion molecule (ICAM)–1 was available. Similar to mouse neutrophils, this …
intercellular adhesion molecule (ICAM)–1 was available. Similar to mouse neutrophils, this …
Multiplex optical sensing with surface-enhanced Raman scattering: a critical review
Multiplex analysis permits the detection of several analytical targets at the same time. This
approach may permit to draw a rapid and accurate diagnostic about the health of an …
approach may permit to draw a rapid and accurate diagnostic about the health of an …
Flow cytometry for high-throughput, high-content screening
Flow cytometry is a mature platform for quantitative multi-parameter measurement of cell
fluorescence. Recent innovations allow up to 30-fold faster serial processing of bulk cell …
fluorescence. Recent innovations allow up to 30-fold faster serial processing of bulk cell …
[HTML][HTML] Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors
R Sridharan, J Zuber, SM Connelly, E Mathew… - … et Biophysica Acta (BBA …, 2014 - Elsevier
G protein coupled receptors are responsible for a wide variety of signaling responses in
diverse cell types. Despite major advances in the determination of structures of this class of …
diverse cell types. Despite major advances in the determination of structures of this class of …
Evaluation of optical detection platforms for multiplexed detection of proteins and the need for point-of-care biosensors for clinical use
S Spindel, KE Sapsford - Sensors, 2014 - mdpi.com
This review investigates optical sensor platforms for protein multiplexing, the ability to
analyze multiple analytes simultaneously. Multiplexing is becoming increasingly important …
analyze multiple analytes simultaneously. Multiplexing is becoming increasingly important …
Direct and propagated effects of small molecules on protein–protein interaction networks
Networks of protein–protein interactions (PPIs) link all aspects of cellular biology.
Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease …
Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease …