Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

Alternative RNA splicing plays an important role in cancer. To determine which factors
involved in RNA processing are essential in prostate cancer, we performed a genome-wide …

Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of
prostate cancer. To compare the genomic alteration landscapes of EO-PCA with" …

Context Given the highly variable behavior and clinical course of prostate cancer (PCa) and
the multiple available treatment options, a personalized approach to oncologic risk …

Abstract Purpose of Review This review will examine the taxonomy of PCa subclasses
across disease states, explore the relationship among specific alterations, and highlight …

Abstract Background Prostate cancer (PCa) molecular subtypes have been defined by
essentially mutually exclusive events, including ETS gene fusions (most commonly involving …

Prostate cancer is driven by a combination of genetic and/or epigenetic alterations.
Epigenetic alterations are frequently observed in all human cancers, yet how aberrant …

Prostate cancer is the second most common cancer among men worldwide. Alterations in
the DNA methylation pattern can be one of the leading causes for prostate cancer formation …

Prostate cancer co-opts a unique set of cellular pathways in its initiation and progression.
The heterogeneity of prostate cancers is evident at earlier stages, and has led to rigorous …