The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Antigen presentation is essential for establishing immune tolerance and for immune
responses against infectious disease and cancer. Although antigen presentation can be …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Despite widespread distribution of LAMP1 and the heterogeneous nature of LAMP1-labeled
compartments, LAMP1 is routinely used as a lysosomal marker, and LAMP1-positive …

Exosomes are extracellular vesicles released upon fusion of multivesicular bodies (MVBs)
with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) during the …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Energy stress, such as ischemia, induces mitochondrial damage and death in the heart.
Degradation of damaged mitochondria by mitophagy is essential for the maintenance of …

The endosomal network comprises an interconnected network of membranous
compartments whose primary function is to receive, dissociate, and sort cargo that originates …

The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …