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Immune effector cell–associated hematotoxicity: EHA/EBMT consensus grading and best practice recommendations
Hematological toxicity is the most common adverse event after chimeric antigen receptor
(CAR) T-cell therapy. Cytopenias can be profound and long-lasting and can predispose for …
(CAR) T-cell therapy. Cytopenias can be profound and long-lasting and can predispose for …
Infections after chimeric antigen receptor (CAR)‐T‐cell therapy for hematologic malignancies
Background Chimeric antigen receptor (CAR)‐T‐cell therapies have revolutionized the
management of acute lymphoblastic leukemia, non‐Hodgkin lymphoma, and multiple …
management of acute lymphoblastic leukemia, non‐Hodgkin lymphoma, and multiple …
CAR-HEMATOTOX: a model for CAR T-cell–related hematologic toxicity in relapsed/refractory large B-cell lymphoma
Hematotoxicity represents a frequent chimeric antigen receptor (CAR) T-cell–related
adverse event and remains poorly understood. In this multicenter analysis, we studied …
adverse event and remains poorly understood. In this multicenter analysis, we studied …
The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL
K Rejeski, A Perez, G Iacoboni… - Journal for …, 2022 - pmc.ncbi.nlm.nih.gov
Background CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) represents a
promising treatment modality for an increasing number of B-cell malignancies. However …
promising treatment modality for an increasing number of B-cell malignancies. However …
The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma
Abstract Background BCMA-directed CAR T-cell therapy (CAR-T) has altered the treatment
landscape of relapsed/refractory (r/r) multiple myeloma, but is hampered by unique side …
landscape of relapsed/refractory (r/r) multiple myeloma, but is hampered by unique side …
Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion
K Rejeski, A Perez, G Iacoboni, V Blumenberg… - Science …, 2023 - science.org
Prolonged cytopenias after chimeric antigen receptor (CAR) T cell therapy are a significant
clinical problem and the underlying pathophysiology remains poorly understood. Here, we …
clinical problem and the underlying pathophysiology remains poorly understood. Here, we …
Infectious complications, immune reconstitution, and infection prophylaxis after CD19 chimeric antigen receptor T-cell therapy
K Wudhikarn, MA Perales - Bone marrow transplantation, 2022 - nature.com
CD19-targeted chimeric antigen receptor (CAR) T-cell becomes a breakthrough therapy
providing excellent remission rates and durable disease control for patients with …
providing excellent remission rates and durable disease control for patients with …
Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality
Cytopenias represent the most common side effect of CAR T-cell therapy (CAR-T) and can
predispose for severe infectious complications. Current grading systems, such as the …
predispose for severe infectious complications. Current grading systems, such as the …
The CAR‐HEMATOTOX score identifies patients at high risk for hematological toxicity, infectious complications, and poor treatment outcomes following …
Abstract CD19‐directed CAR T‐cell therapy with brexucabtagene autoleucel (brexu‐cel)
has substantially improved treatment outcomes for patients with relapsed/refractory mantle …
has substantially improved treatment outcomes for patients with relapsed/refractory mantle …
Infectious complications of CAR T-cell therapy: a clinical update
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary treatment modality used to
treat haematological malignancies. Lymphocytes are engineered to produce CARs directed …
treat haematological malignancies. Lymphocytes are engineered to produce CARs directed …