Heterotopic ossification: a comprehensive review

C Meyers, J Lisiecki, S Miller, A Levin, L Fayad… - JBMR …, 2019 - Wiley Online Library
Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Macrophages in heterotopic ossification: from mechanisms to therapy

Y Huang, X Wang, D Zhou, W Zhou, F Dai… - NPJ Regenerative …, 2021 - nature.com
Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

K Hino, K Horigome, M Nishio… - The Journal of …, 2017 - Am Soc Clin Investig
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized
by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor …

Heterotopic ossification of tendon and ligament

Q Zhang, D Zhou, H Wang, J Tan - Journal of cellular and …, 2020 - Wiley Online Library
Much of the similarities of the tissue characteristics, pathologies and mechanisms of
heterotopic ossification (HO) formation are shared between HO of tendon and ligament …

In vivo dynamic analysis of BMP-2-induced ectopic bone formation

K Hashimoto, T Kaito, M Furuya, S Seno, D Okuzaki… - Scientific reports, 2020 - nature.com
Abstract Bone morphogenetic protein (BMP)-2 plays a central role in bone-tissue
engineering because of its potent bone-induction ability. However, the process of BMP …

Neurological heterotopic ossification: current understanding and future directions

RD Brady, SR Shultz, SJ McDonald, TJ O'Brien - Bone, 2018 - Elsevier
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue
following a neurological condition, of which the most common are brain and spinal cord …

Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis

D Li, Y Jiang, P He, Y Li, Y Wu, W Lei, N Liu… - Advanced …, 2023 - Wiley Online Library
Heterotopic ossification (HO) is a double‐edged sword. Pathological HO presents as an
undesired clinical complication, whereas controlled heterotopic bone formation by synthetic …

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva

KL Wentworth, U Masharani… - British Journal of Clinical …, 2019 - Wiley Online Library
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which heterotopic
bone forms in muscle and soft tissue, leading to joint dysfunction and significant disability …

Challenges of heterotopic ossification—molecular background and current treatment strategies

P Łęgosz, K Drela, Ł Pulik… - Clinical and …, 2018 - Wiley Online Library
Heterotopic ossification (HO) is an abnormal formation of mature lamellar bone within
extraskeletal soft tissues, such as muscles, tendons, and ligaments. This process is thought …

Primary cilia mediate skeletogenic BMP and Hedgehog signaling in heterotopic ossification

K He, H Jiang, W Li, S Toutounchi, Y Huang… - Science translational …, 2024 - science.org
Heterotopic ossification (HO), defined as the formation of extraskeletal bone in muscle and
soft tissues, is a diverse pathological process caused by either genetic mutations or inciting …