MicroRNAs: biological regulators in pathogen–host interactions
An inflammatory response is essential for combating invading pathogens. Several effector
components, as well as immune cell populations, are involved in mounting an immune …
components, as well as immune cell populations, are involved in mounting an immune …
The pathogenicity and virulence of Leishmania-interplay of virulence factors with host defenses
Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …
genus Leishmania. Infection by different species of Leishmania results in various host …
Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine …
Leishmania (Leishmania) amazonensis is an intracellular protozoan parasite responsible for
the cutaneous leishmaniasis. The parasite replicates inside mammalian macrophage to …
the cutaneous leishmaniasis. The parasite replicates inside mammalian macrophage to …
Leishmania-Host Interactions—An Epigenetic Paradigm
Leishmaniasis is one of the major neglected tropical diseases, for which no vaccines exist.
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …
Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression
JCR Fernandes, JI Aoki, S Maia Acuña… - Frontiers in Cellular …, 2019 - frontiersin.org
Leishmaniases are neglected diseases that cause a large spectrum of clinical
manifestations, from cutaneous to visceral lesions. The initial steps of the inflammatory …
manifestations, from cutaneous to visceral lesions. The initial steps of the inflammatory …
MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages
HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to
negate their action on target mRNAs. Here we have identified how HuR, by inducing …
negate their action on target mRNAs. Here we have identified how HuR, by inducing …
Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani
The disease visceral leishmaniasis (VL) or kala azar is caused by the protozoan parasite,
Leishmania donovani (LD). For many decades the pentavalent antimonial drugs countered …
Leishmania donovani (LD). For many decades the pentavalent antimonial drugs countered …
Going ballistic: Leishmania nuclear subversion of host cell plasticity
H Lecoeur, E Prina, M Gutiérrez-Sanchez… - Trends in …, 2022 - cell.com
Intracellular parasites have evolved intricate strategies to subvert host cell functions for their
own survival. These strategies are particularly damaging to the host if the infection involves …
own survival. These strategies are particularly damaging to the host if the infection involves …
Leishmania species‐dependent functional duality of toll‐like receptor 2
Toll‐like receptors (TLRs) are a subset of pattern recognition receptors (PRR) in innate
immunity and act as a connecting link between innate and adaptive immune systems …
immunity and act as a connecting link between innate and adaptive immune systems …
The miRNA 361-3p, a regulator of GZMB and TNF is associated with therapeutic failure and longer time healing of cutaneous leishmaniasis caused by L.(viannia) …
TS Lago, JA Silva, EL Lago, EM Carvalho… - Frontiers in …, 2018 - frontiersin.org
L.(viannia) braziliensis infection causes American Tegumentary Leishmaniasis (ATL), with
prolonged time to healing lesions. The potent inflammatory response developed by the host …
prolonged time to healing lesions. The potent inflammatory response developed by the host …