Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

The emerging therapeutic strategies for osteoarthritis (OA) are shifting toward
comprehensive approaches that target periarticular tissues, involving both cartilage and …

Mitophagy mediated by BNIP3 and NIX critically regulates mitochondrial mass. Cellular
BNIP3 and NIX levels are tightly controlled by SCF FBXL4-mediated ubiquitination to …

DNA molecules have shown potential for drug delivery owing to their predictability and
programmability. Due to the continuous development of DNA nanotechnology and the …

Background: Metabolic syndrome is related to cardiovascular diseases, which is attributed in
part, to arterial stiffness; however, the mechanisms remain unclear. The present study aimed …

Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful
microbes. They are instrumental in initiating innate and adaptive immune responses against …

In eukaryotic cells, N6-methyladenosine (m6A) is the most prevalent RNA epigenetic
modification that plays crucial roles in multiple biological processes. Nevertheless, the …

Malignant tumor has become a major threat affecting human health, and is one of the main
causes of human death. Recent studies have shown that many traditional Chinese …

Reversible phosphorylation of proteins is an important mechanism that regulates cellular
processes, which are precisely regulated by protein kinases and phosphatases. PPM1B is a …