Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

The present invention relates to an immunogenic composi tion. More particularly, the
present invention is a composition directed to eliciting an immune response to at least one …

The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

Long, short and medium chain fatty acids are covalently attached to hundreds of proteins.
Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate …

Protein N-myristoylation is an important fatty acylation catalyzed by N-myristoyltransferases
(NMTs), which are ubiquitous enzymes in eukaryotes. Specifically, attachment of a myristoyl …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

Over the past several decades, extensive research into the Gag polyprotein, the main
structural protein of HIV-1 and all other retroviruses, has changed the way that we describe …

The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that acts as a master
metabolic regulator to maintain cellular energy balance following increased energy demand …