A large number of studies have reported on spontaneous viral clearance rates in acute
hepatitis C infection, however most have been small, and reported rates have varied quite …

Genetic resistance to infectious diseases is likely to involve a complex array of immune-
response and other genes with variants that impose subtle but significant consequences on …

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of
infected persons; approximately 50% of these do not respond to therapy. We performed a …

Hepatitis C virus (HCV) infection remains a major global health burden. Hepatitis C causes
significant liver-related morbidity and mortality due to hepatic decompensation and …

Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with
chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune …

Hepatitis C has emerged in recent years as the most common basis for liver disease in the
United States, having infected an estimated 3.9 million people in this country and an …

Soon after non-A, non-B hepatitis was recognized and a decade and a half before hepatitis
C virus (HCV) was discovered, it was apparent that acute hepatitis after blood transfusion …

Hepatitis C virus (HCV) sets up persistent infection in the majority of those exposed. It is
likely that, as with other persistent viral infections, the efficacy of T-lymphocyte responses …

Abstract Before Robert Koch's work in the late nineteenth century, diseases such as
tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of …

Persistent virus infections create specific problems for their hosts. Although the dynamics of
immune responses after acute infection are well studied and very consistent, especially in …