The golden age of transfer hydrogenation

D Wang, D Astruc - Chemical reviews, 2015 - ACS Publications
Hydrogenation is one of the most fundamental transformations in organic synthesis, and its
industrial applications span from fine chemicals to pharmaceuticals synthesis. 1− 3 Direct …

Catalytic asymmetric transfer hydrogenation of ketones: recent advances

F Foubelo, C Najera, M Yus - Tetrahedron: Asymmetry, 2015 - Elsevier
In this review, we consider the main processes for the asymmetric transfer hydrogenation of
ketones from 2008 up today. The most effective organometallic compounds (derived from …

Ketoreductase catalyzed (dynamic) kinetic resolution for biomanufacturing of chiral chemicals

C Huang, J Liu, J Fang, X Jia, Z Zheng… - … in Bioengineering and …, 2022 - frontiersin.org
Biocatalyzed asymmetric reduction of ketones is an environmentally friendly approach and
one of the most cost-effective routes for producing chiral alcohols. In comparison with the …

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

SK Gediya, GJ Clarkson, M Wills - The Journal of Organic …, 2020 - ACS Publications
A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH)
through a dynamic kinetic resolution (DKR). The protecting group was matched to the …

Development of Asymmetric Transfer Hydrogenation with a Bifunctional Oxo-Tethered Ruthenium Catalyst in Flow for the Synthesis of a Ceramide (d-erythro-CER …

T Touge, M Kuwana, Y Komatsuki… - … Process Research & …, 2018 - ACS Publications
The development of an efficient synthetic route for an optically active ceramide compound (d-
erythro-CER [NDS]) is described. The route proceeds through asymmetric transfer …

Asymmetric reduction of electron-rich ketones with tethered Ru (II)/TsDPEN catalysts using formic acid/triethylamine or aqueous sodium formate

R Soni, TH Hall, BP Mitchell, MR Owen… - The Journal of organic …, 2015 - ACS Publications
The asymmetric transfer hydrogenation (ATH) of ketones under aqueous conditions using
tethered Ru (II)/η6-arene/diamine catalysts is described, as is the ATH of electron-rich …

Asymmetric transfer hydrogenation of functionalized acetylenic ketones

Z Fang, M Wills - The Journal of Organic Chemistry, 2013 - ACS Publications
Asymmetric Transfer Hydrogenation of Functionalized Acetylenic Ketones | The Journal of
Organic Chemistry ACS ACS Publications C&EN CAS Find my institution Log In The …

Synthesis of Nitrogen‐Containing Heterocycles and Cyclopentenone Derivatives via Phosphine‐Catalyzed Michael Addition/Intramolecular Wittig Reaction

N Saleh, F Blanchard, A Voituriez - Advanced Synthesis & …, 2017 - Wiley Online Library
The phosphine‐catalyzed Michael addition/intramolecular Wittig reaction between dialkyl
acetylenedicarboxylate and amino‐carbaldehyde or amino ester derivatives has been …

Highly Enantioselective Synthesis of syn-β-Hydroxy α-Dibenzylamino Esters via DKR Asymmetric Transfer Hydrogenation and Gram-Scale Preparation of Droxidopa

G Sun, Z Zhou, Z Luo, H Wang, L Chen, Y Xu, S Li… - Organic …, 2017 - ACS Publications
A highly efficient preparation of enantiomerically pure syn aryl β-hydroxy α-dibenzylamino
esters is reported. The outcome was achieved via dynamic kinetic resolution and …

Enantioselective and diastereoselective Ir-catalyzed hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution

G Gu, J Lu, O Yu, J Wen, Q Yin, X Zhang - Organic letters, 2018 - ACS Publications
An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted
β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were …