This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …

N-glycosylation is one of the most common types of protein modifications and it plays a vital
role in normal physiological processes. However, aberrant N-glycan modifications are …

Glycosyltransferases of the C superfamily (GT-Cs) are enzymes found in all domains of life.
They catalyse the stepwise synthesis of oligosaccharides or the transfer of assembled …

Nuclear factor κB (NF-κB) plays roles in various diseases. Many inflammatory signals, such
as circulating lipopolysaccharides (LPSs), activate NF-κB via specific receptors. Using whole …

Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification
and degradation of all glycans in Nature. Advances in genomic and metagenomic …

Glycans linked to proteins and lipids and also occurring in free forms have many functions,
and these are partly elicited through specific interactions with glycan-binding proteins …

Congenital disorders of glycosylation (CDG) are rare genetic disorders with a spectrum of
clinical manifestations caused by abnormal N-glycosylation of secreted and cell surface …

N-linked protein glycosylation is a post-translational modification that exists in all domains of
life. It involves two consecutive steps:(i) biosynthesis of a lipid-linked oligosaccharide (LLO) …

The soluble N-glycosyltransferase from Actinobacillus pleuropneumoniae (ApNGT) can
establish an N-glycosidic bond at the asparagine residue in the Asn-Xaa-Ser/Thr consensus …

Glycosyltransferases (GTs) catalyze the addition of sugars to diverse substrates facilitating
complex glycoconjugate biosynthesis across all domains of life. When embedded in or …