Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of
developmental genes largely by catalyzing the formation of mono-ubiquitinated histone H2A …

Parental epigenomes are established during gametogenesis. While they are largely reset
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …

While mouse remains the most popular model, the conservation of parental-to-embryonic
epigenetic transition across mammals is poorly defined. Through analysis of oocytes and …

Little is known about three-dimensional (3D) genome organization in skeletal muscle stem
cells [also called satellite cells (SCs)]. Here, we comprehensively map the 3D genome …