Dissecting the crosstalk between Nrf2 and NF-κB response pathways in drug-induced toxicity

W Gao, L Guo, Y Yang, Y Wang, S **a… - Frontiers in cell and …, 2022 - frontiersin.org
Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

[HTML][HTML] Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

T Pant, N Uche, M Juric, J Zielonka, X Bai - Redox Biology, 2024 - Elsevier
Inflammatory diseases present a serious health challenge due to their widespread
prevalence and the severe impact on patients' lives. In the quest to alleviate the burden of …

Quercetin mitigates cisplatin-induced oxidative damage and apoptosis in cardiomyocytes through Nrf2/HO-1 signaling pathway

SH Wang, KL Tsai, WC Chou, HC Cheng… - The American journal …, 2022 - World Scientific
Cisplatin is massively used to treat solid tumors. However, several severe adverse effects,
such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to …

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Q Hu, W Zhang, F Wei, M Huang, M Shu… - Phytotherapy …, 2024 - Wiley Online Library
This review focuses on the potential ameliorative effects of polyphenolic compounds derived
from human diet on hepatic diseases. It discusses the molecular mechanisms and recent …

Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects

D Singh, MA Khan, HR Siddique - Phytotherapy Research, 2024 - Wiley Online Library
Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds,
biological agents, and medical products. These reactions can manifest as acute or chronic …

The advances in adjuvant therapy for tuberculosis with immunoregulatory compounds

J Mi, X Wu, J Liang - Frontiers in Microbiology, 2024 - frontiersin.org
Tuberculosis (TB) is a chronic bacterial disease, as well as a complex immune disease. The
occurrence, development, and prognosis of TB are not only related to the pathogenicity of …

[HTML][HTML] Deciphering the emerging role of phytocompounds: implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage

MA Ansari, S Shoaib, MN Alomary, H Ather… - Journal of Infection and …, 2023 - Elsevier
Tuberculosis is a disease of poverty, discrimination, and socioeconomic burden.
Epidemiological studies suggest that the mortality and incidence of tuberculosis are …

Nutritional intervention is promising in alleviating liver injury during tuberculosis treatment: a review

Y Fu, X Du, Y Cui, K **ong, J Wang - Frontiers in Nutrition, 2023 - frontiersin.org
Liver injury is a main adverse effect of first-line tuberculosis drugs. Current management of
tuberculosis-drug-induced liver injury (TBLI) mainly relies on withdrawing tuberculosis drugs …

The mechanism of Gejie Zhilao Pill in treating tuberculosis based on network pharmacology and molecular docking verification

Y Gao, B Shang, Y He, W Deng, L Wang… - Frontiers in Cellular and …, 2024 - frontiersin.org
Introduction Gejie Zhilao Pill (GJZLP), a traditional Chinese medicine formula is known for its
unique therapeutic effects in treating pulmonary tuberculosis. The aim of this study is to …

Study on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms

Q Su, Q Liu, J Liu, L Fu, T Liu, J Liang, H Peng… - …, 2021 - Taylor & Francis
The occurrence of antituberculosis drug-induced liver injury affects the effectiveness of
antituberculosis treatments. Understanding the mechanism and risk factors of such liver …