Studies examining the evolution of genomes have focused mainly on sequence
conservation. However, the inner working of a cell implies tightly regulated crosstalk …

Abstract Characterization of the spatiotemporal properties of the chromatin is essential to
gaining insights into the physical bases of gene co-expression, transcriptional regulation …

Mammalian embryonic development is a complex process, characterized by intricate
spatiotemporal dynamics and distinct chromatin preferences. However, the quick …

The spatial organization of the genome plays a critical role in regulating gene expression,
cellular differentiation, and genome stability. This review provides an in-depth examination …

Over a decade has passed since the development of the Hi-C method for genome-wide
analysis of 3D genome organization. Hi-C utilizes next-generation sequencing (NGS) …

Chromatin, with its complex spatial and temporal organization, plays a crucial role in
regulating gene expression. Recent advancements in super-resolution microscopy have …

Architectural stripes in Hi-C and related data are crucial for gene regulation, development,
and DNA repair. Despite their importance, few tools exist for automatic stripe detection. We …

Single-cell Hi-C (scHi-C) has provided unprecedented insights into the heterogeneity of 3D
genome organization. However, its sparse and noisy nature poses challenges for …

Hi-C and micro-C sequencing have shed light on the profound importance of 3D genome
organization in cellular function by probing 3D contact frequencies across the linear …

Mammalian chromosome evolution is highly diverse since a notable variability in
chromosome sizes and diploid numbers has been reported. The hierarchical 3D genome …