[HTML][HTML] Pursuing excitonic energy transfer with programmable DNA-based optical breadboards
DNA nanotechnology has now enabled the self-assembly of almost any prescribed 3-
dimensional nanoscale structure in large numbers and with high fidelity. These structures …
dimensional nanoscale structure in large numbers and with high fidelity. These structures …
In-cell structural biology by NMR: the benefits of the atomic scale
FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …
acids in their native, cellular environment. This emerging field holds great promise and is …
Extreme dynamics in a biomolecular condensate
Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular
condensates,,–. The functions of condensates span many length scales: they modulate …
condensates,,–. The functions of condensates span many length scales: they modulate …
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …
Application of computational biology and artificial intelligence in drug design
Traditional drug design requires a great amount of research time and developmental
expense. Booming computational approaches, including computational biology, computer …
expense. Booming computational approaches, including computational biology, computer …
Visualizing the disordered nuclear transport machinery in situ
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper
for the transport between the nucleus and cytosol. The central channel of the NPC is filled …
for the transport between the nucleus and cytosol. The central channel of the NPC is filled …
Thermal stability enhancement: Fundamental concepts of protein engineering strategies to manipulate the flexible structure
Increasing the temperature by just a few degrees may lead to structural perturbation or
unfolding of the protein and consequent loss of function. The concepts of flexibility and …
unfolding of the protein and consequent loss of function. The concepts of flexibility and …
Interaction dynamics of intrinsically disordered proteins from single-molecule spectroscopy
Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories
Single-molecule FRET (smFRET) is a versatile technique to study the dynamics and function
of biomolecules since it makes nanoscale movements detectable as fluorescence signals …
of biomolecules since it makes nanoscale movements detectable as fluorescence signals …
The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex
Inorganic polyphosphate (polyP) is an ancient energy metabolite and phosphate store that
occurs ubiquitously in all organisms. The vacuolar transporter chaperone (VTC) complex …
occurs ubiquitously in all organisms. The vacuolar transporter chaperone (VTC) complex …