Quantum chemical calculations have been used in the development of synthetic
methodologies to analyze the reaction mechanisms of the developed reactions. Their ability …

We report a general and functional-group-tolerant method for the Cu-catalyzed amination of
base-sensitive aryl bromides including substrates possessing acidic functional groups and …

Copper complexes are widely used in the synthesis of fine chemicals and materials to
catalyze couplings of heteroatom nucleophiles with aryl halides. We show that cross …

Advancements in fine chemical synthesis and drug discovery continuously demand the
development of new and more efficient catalytic systems. In this regard, numerous transition …

Data science is assuming a pivotal role in guiding reaction optimization and streamlining
experimental workloads in the evolving landscape of synthetic chemistry. A discipline-wide …

Hydroxylated (hetero) arenes are privileged motifs in natural products, materials, small‐
molecule pharmaceuticals and serve as versatile intermediates in synthetic organic …

In this Letter, we report that the air-stable “naked nickel”[Ni (4-t Bustb) 3] is a competent
catalyst in thermal C–N bond formation between (hetero) aryl bromides and N-based …

Transition-metal-catalyzed amination of aryl halides is one of the most employed methods
for constructing N-arylation adducts. However, the broad success of these reactions largely …

We report a mild method for the copper-catalyzed amination of aryl chlorides. Key to the
success of the method was the use of highly sterically encumbered N 1, N 2-diaryl diamine …

Cross-coupling reactions play a vital role in modern organic synthesis, enabling the
construction of necessary C–C or C–(het) atom bonds for synthetic transformations …