This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Tissue engineering embraces the potential of recreating and replacing defective body parts
by advancements in the medical field. Being a biocompatible nanomaterial with outstanding …

Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Primary hepatocytes are commonly used as liver surrogates in toxicology and tissue
engineering fields, therefore, maintenance of functional hepatocytes in vitro is an important …

In recent years the interest in liver cell therapy has been increasing continuously, since the
demand for whole liver transplantations in human beings far outweighs the supply. From the …

Human mesenchymal stem cells (hMSCs) are a critical raw material for many regenerative
medicine products, including cell-based therapies, engineered tissues, or combination …

Fatty liver is a significant risk factor for liver transplantation, and accounts for nearly half of
the livers rejected from the donor pool. We hypothesized that metabolic preconditioning via …

Liver diseases are of major concern as they now account for millions of deaths annually. As
a result of the increased incidence of liver disease, many patients die on the transplant …

Orthotopic liver transplantation remains the only curative treatment for liver disease.
However, the number of patients who die while on the waiting list (15%) has increased in …